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The primary outcome must include participants self-reported smoking status and a biochemically verified smoking abstinence

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This quote reflected his open-mindedness while conducting his research: My personal guess right now is that there is a cause-and-effect relationship between smoking and lung cancer, but I have no idea at the present time whether that relationship is trivialno more dangerous than crossing the street, for after all, you might get run over crossing the streetor whether it is so important that making cigarettes ought to stop until we found whats in them that is bad and remove it